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Premature chromatin condensation upon accumulation of NIMA.

Abstract:

The NIMA protein kinase of Aspergillus nidulans is required for the G2/M transition of the cell cycle. Mutants lacking NIMA arrest without morphological characteristics of mitosis, but they do contain an activated p37nimX kinase (the Aspergillus homologue of p34cdc2). To gain a better understanding of NIMA function we have investigated the effects of expressing various NIMA constructs in Aspergillus, fission yeast and human cells. Our experiments have shown that the instability of the NIMA pr...

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Publication status:
Published

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Authors


O'Connell, MJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
The EMBO journal
Volume:
13
Issue:
20
Pages:
4926-4937
Publication date:
1994-10-05
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:34339dee-4973-480b-8c39-b898c796bf0b
Source identifiers:
24775
Local pid:
pubs:24775

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