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Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases.

Abstract:

Animals employ two systems for the de novo biosynthesis of fatty acids: a megasynthase complex in the cytosol (type I) that produces mainly palmitate, and an ensemble of freestanding enzymes in the mitochondria (type II) that produces mainly octanoyl moieties. The acyltransferases responsible for initiation of fatty acid biosynthesis in the two compartments are distinguished by their different substrate specificities: the type I enzyme transfers both the acetyl primer and the malonyl chain ex...

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Authors


Bunkoczi, Gabor More by this author
Misquitta, Stephanie More by this author
Wu, Xiaoqiu More by this author
Lee, Wen Hwa More by this author
Rojkova, Alexandra More by this author
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Journal:
Chemistry and biology
Volume:
16
Issue:
6
Pages:
667-75
Publication date:
2009
ISSN:
1879-1301
URN:
uuid:343232d9-a7b7-43fd-8059-cd63fc05c8c9
Local pid:
SGC:19549604

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