Comprehensive molecular cytogenetic analysis of the human blastocyst stage.

Journal article

BACKGROUND: The high frequency of chromosomal abnormalities observed in human gametes and embryos is unlike that seen in other mammalian species and is of great clinical significance, leading to high rates of pregnancy loss, and live-born children with aneuploid syndromes. Although much is known concerning the aneuploidy rates of oocytes, cleavage stage embryos and fetuses during pregnancy, the chromosomal status of blastocysts has been relatively little investigated. METHODS: A total of 158...

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Authors: Fragouli, E; Lenzi, M; Ross, R; Katz-Jaffe, M; Schoolcraft, W

• Publication status: Published
• Journal: Human reproduction (Oxford, England)
• Volume: 23
• Issue: 11
• Pages: 2596-2608
• Publication date: 2008-11-01
• DOI: 10.1093/humrep/den287
• EISSN: 1460-2350
• ISSN: 0268-1161
• Language: English
• Keywords: Preimplantation Diagnosis; Embryo Transfer; Nucleic Acid Hybridization; In Situ Hybridization, Fluorescence; Blastocyst; Chromosomes; Humans; Aneuploidy; Ovulation Induction; Genetic Techniques; Female; Middle Aged; Cytogenetics; Adult; Male