Journal article
A one-pot synthesis-functionalization strategy for streamlined access to 2,5-disubstituted 1,3, 4-oxadiazoles from carboxylic acids
- Abstract:
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A one-pot 1,3,4-oxadiazole synthesis-arylation strategy for accessing 2,5-disubstituted 1,3,4-oxadiazoles, from carboxylic acids, N-isocyaniminotriphenylphosphorane (NIITP), and aryl iodides, is reported. The reaction sequence, featuring a second stage copper-catalyzed 1,3,4-oxadiazole arylation, was found to tolerate (hetero)aryl, alkyl, and alkenyl carboxylic acids, and (hetero)aryl iodide coupling partners. The effectiveness of the two-stage strategy was exemplified by the...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.0MB, Terms of use)
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- Publisher copy:
- 10.1021/acs.joc.2c01669
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Funding
Bibliographic Details
- Publisher:
- American Chemical Society
- Journal:
- Journal of Organic Chemistry More from this journal
- Volume:
- 87
- Issue:
- 18
- Pages:
- 12498-12505
- Publication date:
- 2022-09-02
- Acceptance date:
- 2022-09-02
- DOI:
- EISSN:
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1520-6904
- ISSN:
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0022-3263
- Pmid:
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36054913
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1278258
- Local pid:
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pubs:1278258
- Deposit date:
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2023-10-03
Terms of use
- Copyright holder:
- Matheau-Raven and Dixon
- Copyright date:
- 2022
- Rights statement:
- Copyright © 2022 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0.
- Licence:
- CC Attribution (CC BY)
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