- Abstract:
-
11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) interconverts inactive cortisone and active cortisol. Although bidirectional, in vivo it is believed to function as a reductase generating active glucocorticoid at a prereceptor level, enhancing glucocorticoid receptor activation. In this review, we discuss both the genetic and enzymatic characterization of 11beta-HSD1, as well as describing its role in physiology and pathology in a tissue-specific manner. The molecular basis of cortiso...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1210/er.2003-0031
-
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- Journal:
- Endocrine reviews
- Volume:
- 25
- Issue:
- 5
- Pages:
- 831-866
- Publication date:
- 2004-10-05
- DOI:
- EISSN:
-
1945-7189
- ISSN:
-
0163-769X
- URN:
-
uuid:340cf4d4-c4a9-437b-936d-919a5cc794bc
- Source identifiers:
-
125554
- Local pid:
- pubs:125554
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
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