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11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.

Abstract:

11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) interconverts inactive cortisone and active cortisol. Although bidirectional, in vivo it is believed to function as a reductase generating active glucocorticoid at a prereceptor level, enhancing glucocorticoid receptor activation. In this review, we discuss both the genetic and enzymatic characterization of 11beta-HSD1, as well as describing its role in physiology and pathology in a tissue-specific manner. The molecular basis of cortiso...

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Publication status:
Published

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Publisher copy:
10.1210/er.2003-0031

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Walker, EA More by this author
Bujalska, IJ More by this author
Lavery, GG More by this author
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Journal:
Endocrine reviews
Volume:
25
Issue:
5
Pages:
831-866
Publication date:
2004-10-05
DOI:
EISSN:
1945-7189
ISSN:
0163-769X
URN:
uuid:340cf4d4-c4a9-437b-936d-919a5cc794bc
Source identifiers:
125554
Local pid:
pubs:125554

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