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11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.

Abstract:

11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) interconverts inactive cortisone and active cortisol. Although bidirectional, in vivo it is believed to function as a reductase generating active glucocorticoid at a prereceptor level, enhancing glucocorticoid receptor activation. In this review, we discuss both the genetic and enzymatic characterization of 11beta-HSD1, as well as describing its role in physiology and pathology in a tissue-specific manner. The molecular basis of cortiso...

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Publication status:
Published

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Publisher copy:
10.1210/er.2003-0031

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Journal:
Endocrine reviews
Volume:
25
Issue:
5
Pages:
831-866
Publication date:
2004-10-01
DOI:
EISSN:
1945-7189
ISSN:
0163-769X
Source identifiers:
125554

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