Journal article icon

Journal article

Ion-blocking sites of the Kir2.1 channel revealed by multiscale modeling.

Abstract:

The Kir2.1 potassium channel owes its inward-rectifying behavior to blocking by multivalent ions, e.g., magnesium and spermine, which access the channel from the cytoplasm and are thought to bind within the pore. To investigate the pathway followed by these ions from the cytoplasm through the pore, we have used multiscale modeling (via continuum electrostatics calculations, docking, and molecular dynamics simulations) to identify possible binding sites en route. On its way to eventually bindi...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/bi9007808

Authors


Journal:
Biochemistry
Volume:
48
Issue:
36
Pages:
8758-8763
Publication date:
2009-09-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:3407520a-bc94-4622-8ac0-8c7ae9b16866
Source identifiers:
100527
Local pid:
pubs:100527

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP