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Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression

Abstract:

Neurochemical markers of amyotrophic lateral sclerosis (ALS) that reflect underlying disease mechanisms might help in diagnosis, staging and prediction of outcome. We aimed at determining the origin and differential diagnostic and prognostic potential of the putative marker of microglial activation chitotriosidase (CHIT1).Altogether 316 patients were included, comprising patients with sporadic ALS, ALS mimics (disease controls (DCo)), frontotemporal lobar degeneration (FTLD), Creutzfeldt-Jako...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/jnnp-2017-317138

Authors


Steinacker, P More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
ORCID:
0000-0001-5905-3826
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ORCID:
0000-0002-7652-7023
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
Journal of Neurology, Neurosurgery and Psychiatry Journal website
Volume:
89
Issue:
3
Pages:
239-247
Publication date:
2017-11-15
Acceptance date:
2017-10-04
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
Pubs id:
pubs:747476
URN:
uri:33f39dce-e636-407b-8046-72b100fb0ac0
UUID:
uuid:33f39dce-e636-407b-8046-72b100fb0ac0
Local pid:
pubs:747476
Language:
English

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