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Discordance between accumulated p53 protein level and its transcriptional activity in response to u.v. radiation.

Abstract:

In response to DNA damage, the transcriptional activity of p53 rises. This has been thought to be due to an increase in the level of p53 protein. By comparing the p53 protein level and its ability to transactivate target genes Waf1/Cip1 and mdm2 in both T22 and NIH3T3 cells irradiated with u.v., a discordance between the p53 protein level and its transcriptional activity was observed. When the cells were irradiated with 10 J/m2 of u.v., there was a substantial increase in expression of Waf1/ ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Role:
Author
Journal:
Oncogene
Volume:
13
Issue:
2
Pages:
413-418
Publication date:
1996-07-05
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:33e79b49-e6dc-4ec2-a2cd-e3afc3dccbd2
Source identifiers:
84024
Local pid:
pubs:84024

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