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A Multi-Crystal Method for Extracting Obscured Crystallographic States from Conventionally Uninterpretable Electron Density

Abstract:

In macromolecular crystallography, the rigorous detection of changed states (for example, ligand binding) is difficult unless signal is strong. Ambiguous (‘weak’ or ‘noisy’) density is experimentally common, since molecular states are generally only fractionally present in the crystal. Existing methodologies focus on generating maximally accurate maps whereby minor states become discernible; in practice, such map interpretation is disappointingly subjective, time-consuming and methodologicall...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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10.1038/ncomms15123

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
Role:
Author
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Funding agency for:
Pearce, N
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Funding agency for:
Pearce, N
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Funding agency for:
Deane, C
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Issue:
15123
Publication date:
2017-04-24
Acceptance date:
2017-03-13
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:689210
URN:
uri:33e63edb-a354-40f8-a0b1-c1535b180b62
UUID:
uuid:33e63edb-a354-40f8-a0b1-c1535b180b62
Local pid:
pubs:689210
Paper number:
15123

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