Journal article
A Multi-Crystal Method for Extracting Obscured Crystallographic States from Conventionally Uninterpretable Electron Density
- Abstract:
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In macromolecular crystallography, the rigorous detection of changed states (for example, ligand binding) is difficult unless signal is strong. Ambiguous (‘weak’ or ‘noisy’) density is experimentally common, since molecular states are generally only fractionally present in the crystal. Existing methodologies focus on generating maximally accurate maps whereby minor states become discernible; in practice, such map interpretation is disappointingly subjective, time-consuming and methodologicall...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.3MB)
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- Publisher copy:
- 10.1038/ncomms15123
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Authors
Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Pearce, N
Grant:
EP/G037280/1
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Deane, C
Grant:
EP/G037280/1
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 8
- Issue:
- 15123
- Publication date:
- 2017-04-24
- Acceptance date:
- 2017-03-13
- DOI:
- EISSN:
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2041-1723
- ISSN:
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2041-1723
- Source identifiers:
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689210
Item Description
- Pubs id:
-
pubs:689210
- UUID:
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uuid:33e63edb-a354-40f8-a0b1-c1535b180b62
- Local pid:
- pubs:689210
- Deposit date:
- 2017-04-12
Terms of use
- Copyright holder:
- Pearce et al
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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