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The role of plasma and vascular tetrahydrobiopterin in vascular disease states

Abstract:

The endothelial nitric oxide synthase (eNOS) co-factor tetrahydrobiopterin (BH4) has been shown to play a pivotal role in maintaining endothelial function in experimental vascular disease models. In BH4-deficient states, eNOS becomes enzymatically ‘uncoupled’, generating reactive oxygen species instead of nitric oxide, thus promoting endothelial dysfunction. In humans with coronary artery disease (CAD), higher vascular BH4 levels have been shown to be associated with improved endothelial f...

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Institution:
University of Oxford
Oxford college:
St Catherine's College
Department:
Medical Sciences Division - Cardiovascular Medicine

Contributors

Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:33df2f8a-f16b-4271-988a-4500ed89d35e
Local pid:
ora:6444

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