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Journal article

Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

Abstract:

Efficient stop codon recognition and peptidyl-tRNA hydrolysis are essential in order to terminate translational elongation and maintain protein sequence fidelity. Eukaryotic translational termination is mediated by a release factor complex that includes eukaryotic release factor 1 (eRF1) and eRF3. The N terminus of eRF1 contains highly conserved sequence motifs that couple stop codon recognition at the ribosomal A site to peptidyl-tRNA hydrolysis. We reveal that Jumonji domain-containing 4 (J...

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Publication status:
Published

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Authors


Yamamoto, A More by this author
Wilkins, SE More by this author
Sokolova, E More by this author
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Journal:
Molecular cell
Volume:
53
Issue:
4
Pages:
645-654
Publication date:
2014-02-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:33c99cbf-00c8-42c9-ae81-604e7ffa9430
Source identifiers:
447616
Local pid:
pubs:447616

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