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Systematic meta-analyses and field synopsis of genetic and epigenetic studies in paediatric inflammatory bowel disease

Abstract:

We provide a comprehensive field synopsis of genetic and epigenetic associations for paediatric Inflammatory Bowel Disease (IBD). A systematic review was performed and included 84 genetic association studies reporting data for 183 polymorphisms in 71 genes. Meta-analyses were conducted for 20 SNPs in 10 genes of paediatric Crohn’s disease (CD) and for 8 SNPs in 5 genes of paediatric ulcerative colitis (UC). Five epigenetic studies were also included, but formal meta-analysis was not possible....

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/srep34076

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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Publication date:
2016-09-27
Acceptance date:
2016-09-01
DOI:
ISSN:
2045-2322
Pubs id:
pubs:904451
URN:
uri:33c6ce33-86c3-4577-b30f-56d58c281d8a
UUID:
uuid:33c6ce33-86c3-4577-b30f-56d58c281d8a
Local pid:
pubs:904451

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