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A common variant associated with dyslexia reduces expression of the KIAA0319 gene.

Abstract:

Numerous genetic association studies have implicated the KIAA0319 gene on human chromosome 6p22 in dyslexia susceptibility. The causative variant(s) remains unknown but may modulate gene expression, given that (1) a dyslexia-associated haplotype has been implicated in the reduced expression of KIAA0319, and (2) the strongest association has been found for the region spanning exon 1 of KIAA0319. Here, we test the hypothesis that variant(s) responsible for reduced KIAA0319 expression resides on...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1000436

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Institution:
University of Oxford
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Institution:
University of Oxford
Prokunina-Olsson, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Funding agency for:
Dennis, MY
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Funding agency for:
Paracchini, S
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Funding agency for:
Scerri, TS
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
5
Issue:
3
Pages:
Article: e1000436
Publication date:
2009-03-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:33b8a9ed-2e19-4f1e-bba6-8f5f8d7e9a57
Source identifiers:
19489
Local pid:
pubs:19489

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