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Testicular hypofunction and multiple sclerosis risk: A record-linkage study

Abstract:

The influence of gonadal hormones on multiple sclerosis (MS) is not well characterized and has thus far been investigated primarily in animal models or as a proposed therapeutic approach. We investigated a potential association between testicular hypofunction, as a proxy for low testosterone levels, and MS risk through analysis of linked English national Hospital Episode Statistics from 1999 to 2011. We report a strong positive association between testicular hypofunction and subsequent MS (ra...

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Publisher copy:
10.1002/ana.24250

Authors


Pakpoor, J More by this author
Goldacre, R More by this author
Schmierer, K More by this author
Giovannoni, G More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Population Health
Publisher:
John Wiley and Sons Inc.
Journal:
Annals of Neurology
Volume:
76
Issue:
4
Pages:
625-628
Publication date:
2014-10-01
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
URN:
uuid:33b53e86-4d4d-4129-ba90-af5abc0b231d
Source identifiers:
488062
Local pid:
pubs:488062
Language:
English

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