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Journal article

Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNP.

Abstract:

Genetic variation in the metabotropic glutamate receptor 3 (GRM3, mGluR3) has been associated with schizophrenia, but the mechanism by which it confers risk is unknown. Previously, we reported the existence of a splice variant, GRM3Delta4, which has an exon 4 deletion and encodes a truncated form of the receptor that is expressed in brain. The aim of the present study was to determine whether expression of this splice variant is altered in individuals with schizophrenia and is affected by a r...

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Publication status:
Published

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Publisher copy:
10.1038/sj.npp.1301669

Authors


Sartorius, LJ More by this author
Weinberger, DR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Kleinman, JE More by this author
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Journal:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume:
33
Issue:
11
Pages:
2626-2634
Publication date:
2008-10-05
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
URN:
uuid:33b45464-940b-478c-9fbb-2ff17c12383b
Source identifiers:
98087
Local pid:
pubs:98087

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