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A spatiotemporal analysis of gait freezing and the impact of pedunculopontine nucleus stimulation.

Abstract:

Gait freezing is an episodic arrest of locomotion due to an inability to take normal steps. Pedunculopontine nucleus stimulation is an emerging therapy proposed to improve gait freezing, even where refractory to medication. However, the efficacy and precise effects of pedunculopontine nucleus stimulation on Parkinsonian gait disturbance are not established. The clinical application of this new therapy is controversial and it is unknown if bilateral stimulation is more effective than unilatera...

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Publication status:
Published

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Publisher copy:
10.1093/brain/aws039

Authors


Thevathasan, W More by this author
Graepel, CL More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Journal:
Brain : a journal of neurology
Volume:
135
Issue:
Pt 5
Pages:
1446-1454
Publication date:
2012-05-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:33b1bd3b-1407-4a8e-87c1-1a483ca0bdc7
Source identifiers:
316226
Local pid:
pubs:316226

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