GABAB receptors are G-protein coupled receptors that mediate inhibitory synaptic actions through a series of downstream target proteins. It is increasingly appreciated that the GABAB receptor forms part of larger signalling complexes, which enable the receptor to mediate multiple different effects within neurons. Here we report that GABAB receptors can physically associate with the potassium-chloride cotransporter protein, KCC2, which sets the driving force for the chloride permeable ionotrop...Expand abstract
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Copyright © 2017 Wright, Newey et al.
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Neuronal chloride regulation via KCC2 is modulated through a GABAB receptor protein complex
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