Journal article icon

Journal article

Neuronal chloride regulation via KCC2 is modulated through a GABAB receptor protein complex

Abstract:

GABAB receptors are G-protein coupled receptors that mediate inhibitory synaptic actions through a series of downstream target proteins. It is increasingly appreciated that the GABAB receptor forms part of larger signalling complexes, which enable the receptor to mediate multiple different effects within neurons. Here we report that GABAB receptors can physically associate with the potassium-chloride cotransporter protein, KCC2, which sets the driving force for the chloride permeable ionotrop...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1523/JNEUROSCI.2164-16.2017

Authors


More by this author
Department:
Oxford, MSD, Pharmacology
Role:
Author
More by this author
Department:
Oxford, MSD, Pharmacology
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Newey, SE
More from this funder
Funding agency for:
Ilie, A
Publisher:
Society for Neuroscience Publisher's website
Journal:
Journal of Neuroscience Journal website
Volume:
37
Issue:
22
Pages:
5447-5462
Publication date:
2017-05-31
DOI:
ISSN:
1529-2401
Pubs id:
pubs:693458
URN:
uri:33af7b18-65d1-4985-86f0-0ffa83bf37b4
UUID:
uuid:33af7b18-65d1-4985-86f0-0ffa83bf37b4
Local pid:
pubs:693458
Paper number:
22

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP