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Journal article

Characterization of an HLA-C-restricted CTL response in chronic HIV infection.

Abstract:

HIV-specific CTL play an important role in the host control of HIV infection. HIV-nef may facilitate escape of HIV-infected cells from CTL recognition by selectively downregulating the expression of HLA-A and HLA-B molecules, while surface expression of HLA-C is unaffected. The HLA-C-restricted CTL responses have previously been largely ignored and poorly characterized. We examined the frequency, function, and phenotype of HLA-C-restricted CTL in ten antiretroviral therapy-naïve Caucasian and...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200939634

Authors


Makadzange, AT More by this author
Gillespie, G More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
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Journal:
European journal of immunology
Volume:
40
Issue:
4
Pages:
1036-1041
Publication date:
2010-04-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:33a6b9e9-8261-4ca8-b233-622388ebc872
Source identifiers:
46175
Local pid:
pubs:46175

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