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Journal article

Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression

Abstract:

Toll like receptors (TLRs) are important pattern recognition receptors that can detect pathogen and danger associated molecular patterns to initiate an innate immune response. TLR1 and 2 heterodimerize at the plasma membrane upon binding to triacylated lipopeptides from bacterial cell walls, or to the synthetic ligand Pam3CSK4. TLR1/2 dimers interact with adaptor molecules TIRAP and MyD88 to initiate a signalling cascade that leads to activation of key transcription factors, including NF-kB. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0202408

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM - Investigative Medicine Division
Role:
Author
ORCID:
0000-0002-8396-1354
Victorian State Government More from this funder
Australian National Health and Medical Research Council More from this funder
Australian Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
13
Issue:
8
Pages:
e0202408
Publication date:
2018-08-23
Acceptance date:
2018-08-02
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Pubs id:
pubs:911178
URN:
uri:339d39cb-df61-4285-9f95-12a19d8b7543
UUID:
uuid:339d39cb-df61-4285-9f95-12a19d8b7543
Local pid:
pubs:911178
Language:
English
Keywords:

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