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Journal article

A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.

Abstract:

The neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is essential for synaptic vesicle exocytosis, but its study has been limited by the neonatal lethality of murine SNARE knockouts. Here, we describe a viable mouse line carrying a mutation in the b-isoform of neuronal SNARE synaptosomal-associated protein of 25 kDa (SNAP-25). The causative I67T missense mutation results in increased binding affinities within the SNARE complex, impaired exocytotic...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0610222104

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Oliver, PL More by this author
Johnson, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
104
Issue:
7
Pages:
2431-2436
Publication date:
2007-02-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:339a4394-1763-4f4f-a41b-85548050b479
Source identifiers:
6477
Local pid:
pubs:6477

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