Journal article
PYY-dependent restoration of impaired insulin and glucagon secretion in type-2 diabetes following Roux-En-Y gastric bypass surgery
- Abstract:
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Roux-en-Y gastric bypass (RYGB) is a weight-reduction procedure resulting in rapid resolution of type-2 diabetes (T2D). The role of pancreatic islet function in this restoration of normoglycemia has not been fully elucidated. Using the diabetic GK rat model, we demonstrate that RYGB restores normal glucose regulation of glucagon and insulin secretion and normalizes islet morphology. Culture of isolated islets with serum from RYGB animals mimicked these effects, implicating a humoral factor. T...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.4MB, Terms of use)
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- Publisher copy:
- 10.1016/j.celrep.2016.03.091
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Bibliographic Details
- Publisher:
- Cell Press
- Journal:
- Cell Reports More from this journal
- Volume:
- 15
- Issue:
- 5
- Pages:
- 944-950
- Publication date:
- 2016-04-21
- Acceptance date:
- 2016-03-27
- DOI:
- ISSN:
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2211-1247
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Terms of use
- Copyright holder:
- Ramracheya et al
- Copyright date:
- 2016
- Notes:
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Copyright 2016 The Authors
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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