Journal article icon

Journal article

Structural insights into the human metapneumovirus glycoprotein ectodomain.

Abstract:

Human metapneumovirus is a major cause of respiratory tract infections worldwide. Previous reports have shown that the viral attachment glycoprotein (G) modulates innate and adaptive immune responses, leading to incomplete immunity and promoting reinfection. Using bioinformatics analyses, static light scattering, and small-angle X-ray scattering, we show that the extracellular region of G behaves as a heavily glycosylated, intrinsically disordered polymer. We discuss potential implications of...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1128/jvi.01726-14

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
Publisher:
American Society for Microbiology
Journal:
Journal of virology
Volume:
88
Issue:
19
Pages:
11611-11616
Publication date:
2014-10-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:3392025f-7f9b-44cf-b7c8-880278c5c0c0
Source identifiers:
476208
Local pid:
pubs:476208

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP