[123I]-FP-CIT-SPECT demonstrates dopaminergic deficit in orthostatic tremor.

Journal article

There is increasing evidence of a potential role of the dopaminergic system in orthostatic tremor (OT): Association with parkinsonism and treatment effects of L-dopa and dopamine agonists have been reported. Eleven patients with isolated OT had single-photon emission computed tomography (SPECT) using (123)I-FP-CIT ([(123)I]-2 beta-carbomethoxy-3beta-(-4-iodophenyl)-N-(3-fluoropropyl)-nortropane) as dopamine transporter tracer. Results were compared with 12 age-matched normal controls and 12 p...

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Authors: Katzenschlager, R; Costa, D; Gerschlager, W; O'Sullivan, J; Zijlmans, J

• Publication status: Published
• Journal: Annals of neurology
• Volume: 53
• Issue: 4
• Pages: 489-496
• Publication date: 2003-04-01
• DOI: 10.1002/ana.10475
• EISSN: 1531-8249
• ISSN: 0364-5134
• Language: English
• Keywords: Humans; Dopamine Agents; Middle Aged; Tomography, Emission-Computed, Single-Photon; Female; Electromyography; Iodine Radioisotopes; Male; Tropanes; Videotape Recording; Aged; Levodopa; Smell; Tremor; Dopamine; Aged, 80 and over