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Journal article

A fluorous and click approach for screening potential PET probes: Evaluation of potential hypoxia biomarkers.

Abstract:

Radiopharmaceuticals for nuclear imaging are essentially targeting molecules, labeled with short-lived radionuclides (e.g., F-18 for PET). A significant drawback of radiopharmaceuticals development is the difficulty to access radiolabeled molecule libraries for initial in vitro evaluation, as radiolabeling has to be optimized for each individual molecule. The present paper discloses a method for preparing libraries of (18)F-labeled radiopharmaceuticals using both the fluorous-based (18)F-radi...

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Publication status:
Published

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Publisher copy:
10.1016/j.bmc.2011.10.084

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Bioorganic and medicinal chemistry
Volume:
20
Issue:
1
Pages:
324-329
Publication date:
2012-01-05
DOI:
EISSN:
1464-3391
ISSN:
0968-0896
URN:
uuid:338521ee-a22b-45cb-aa6d-4ae013370c03
Source identifiers:
216104
Local pid:
pubs:216104

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