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ICAM-1 co-stimulates target cells to facilitate antigen presentation.

Abstract:

Adhesion molecules are known to mediate cell-cell interactions, particularly those between T cells and antigen-presenting or target cells. Recent studies identified ICAM-1 as a co-stimulatory ligand that binds to lymphocyte function associated antigen-1 (LFA-1), thereby promoting the activation of T cells. As ICAM-1 is expressed on virtually any cell, it becomes a crucial molecule for the activation of CD8(+) T cells in the absence of co-stimulation provided by CD80 and CD86 molecules. In add...

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Publisher copy:
10.1016/j.coi.2005.04.008

Authors


Lebedeva, T More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Sykulev, Y More by this author
Journal:
Current opinion in immunology
Volume:
17
Issue:
3
Pages:
251-258
Publication date:
2005-06-05
DOI:
EISSN:
1879-0372
ISSN:
0952-7915
URN:
uuid:33810c0c-8071-4cb9-bd87-d9795f2093b5
Source identifiers:
482624
Local pid:
pubs:482624

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