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Dual-calibrated fMRI measurement of absolute cerebral metabolic rate of oxygen consumption and effective oxygen diffusivity

Abstract:

Dual-calibrated fMRI is a multi-parametric technique that allows for the quantification of the resting oxygen extraction fraction (OEF), the absolute rate of cerebral metabolic oxygen consumption (CMRO2), cerebral vascular reactivity (CVR) and baseline perfusion (CBF). It combines measurements of arterial spin labelling (ASL) and blood oxygenation level dependent (BOLD) signal changes during hypercapnic and hyperoxic gas challenges. Here we propose an extension to this methodology that permit...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.neuroimage.2018.09.035

Authors


Germuska, M More by this author
Chandler, HL More by this author
Stickland, RC More by this author
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Grant:
Strategic Award, ‘Multi-scale and multi-modal assessment of coupling in the healthy and diseased brain’, grant reference 104943/Z/14/Z
Publisher:
Elsevier Publisher's website
Journal:
NeuroImage Journal website
Volume:
184
Pages:
717-728
Publication date:
2018-09-29
Acceptance date:
2018-09-14
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
Pubs id:
pubs:927070
URN:
uri:337675fe-29ef-4fd9-b535-570dcc404a67
UUID:
uuid:337675fe-29ef-4fd9-b535-570dcc404a67
Local pid:
pubs:927070
Language:
English

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