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Journal article

Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration.

Abstract:

The development of genotyping technologies has allowed for wider screening for inherited causes of variable outcomes following drug administration. We have performed a genome-wide association study (GWAS) on 221 colorectal cancer (CRC) patients that had been treated with 5-fluorouracil (5-FU), either alone or in combination with oxaliplatin (FOLFOX). A validation set of 791 patients was also studied. Seven SNPs (rs16857540, rs2465403, rs10876844, rs10784749, rs17626122, rs7325568 and rs424376...

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Publication status:
Published

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Publisher copy:
10.1038/tpj.2012.2

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Journal:
pharmacogenomics journal
Volume:
13
Issue:
3
Pages:
209-217
Publication date:
2013-06-01
DOI:
EISSN:
1473-1150
ISSN:
1470-269X
Source identifiers:
313882

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