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Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite.

Abstract:

Bisphosphonates are now the most widely used drugs for diseases associated with increased bone resorption, such as osteoporosis. Although bisphosphonates act directly on osteoclasts, and interfere with specific biochemical processes such as protein prenylation, their ability to adsorb to bone mineral also contributes to their potency and duration of action. The aim of the present study was to compare the binding affinities for hydroxyapatite (HAP) of 6 bisphosphonates currently used clinicall...

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Publication status:
Published

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Publisher copy:
10.1016/j.bone.2005.05.003

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Journal:
Bone
Volume:
38
Issue:
5
Pages:
617-627
Publication date:
2006-05-05
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
URN:
uuid:336e9034-2401-428c-ac01-94a0142df75c
Source identifiers:
109086
Local pid:
pubs:109086

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