- Abstract:
-
Bisphosphonates are now the most widely used drugs for diseases associated with increased bone resorption, such as osteoporosis. Although bisphosphonates act directly on osteoclasts, and interfere with specific biochemical processes such as protein prenylation, their ability to adsorb to bone mineral also contributes to their potency and duration of action. The aim of the present study was to compare the binding affinities for hydroxyapatite (HAP) of 6 bisphosphonates currently used clinicall...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.bone.2005.05.003
-
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- Journal:
- Bone
- Volume:
- 38
- Issue:
- 5
- Pages:
- 617-627
- Publication date:
- 2006-05-05
- DOI:
- EISSN:
-
1873-2763
- ISSN:
-
8756-3282
- URN:
-
uuid:336e9034-2401-428c-ac01-94a0142df75c
- Source identifiers:
-
109086
- Local pid:
- pubs:109086
- Language:
- English
- Keywords:
- Copyright date:
- 2006
Journal article
Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite.
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