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Journal article

The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man.

Abstract:

The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commonest cancer in men in the UK. We present a comprehensive analysis of AR binding sites in human prostate cancer tissues, including castrate-resistant prostate cancer (CRPC). We identified thousands of AR binding sites in CRPC tissue, most of which were not identified in PC cell lines. Many adjacent genes showed AR regulation in xenografts but not in cultured LNCaPs, demonstrating an in-vivo-restri...

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Publication status:
Published

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Publisher copy:
10.1016/j.ccr.2012.11.010

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Massie, CE More by this author
Ramos-Montoya, A More by this author
Zecchini, V More by this author
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Journal:
Cancer cell
Volume:
23
Issue:
1
Pages:
35-47
Publication date:
2013-01-05
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
URN:
uuid:336d5809-edc3-4826-b653-635d56402c54
Source identifiers:
376277
Local pid:
pubs:376277

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