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Pharmacokinetics of lopinavir-ritonavir with and without nonnucleoside reverse transcriptase inhibitors in Ugandan HIV-infected adults.

Abstract:

We evaluated the pharmacokinetics of lopinavir-ritonavir with and without nonnucleoside reverse transcriptase inhibitors (NNRTIs) in Ugandan adults. The study design was a three-period crossover study (3 tablets [600 mg of lopinavir/150 mg of ritonavir {600/150 mg}], 4 capsules [533/133 mg], and 2 tablets [400/100 mg] twice a day [BD]; n = 40) of lopinavir-ritonavir with NNRTIs and a parallel one-period study (2 tablets BD; n = 20) without NNRTIs. Six-point pharmacokinetic sampling (0, 2, 4, ...

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Publication status:
Published

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Publisher copy:
10.1128/aac.01198-09

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Dickinson, L More by this author
Lutwama, F More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
54
Issue:
7
Pages:
2965-2973
Publication date:
2010-07-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:3364ebfc-c9e8-496f-a2d8-7cfcd29249c7
Source identifiers:
422932
Local pid:
pubs:422932

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