Journal article icon

Journal article

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.

Abstract:

Aggrecanases, in particular aggrecanase-2 (ADAMTS-5), are considered the principal proteases responsible for aggrecan degradation in osteoarthritis. For this reason, considerable effort has been put on the discovery and development of aggrecanase inhibitors able to slow down or halt the progression of osteoarthritis. We report herein the synthesis and biological evaluation of a series of arylsulfonamido-based hydroxamates as aggrecanase inhibitors. Compound 18 was found to have a nanomolar ac...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
European journal of medicinal chemistry
Volume:
62
Pages:
379-394
Publication date:
2013-04-05
DOI:
EISSN:
1768-3254
ISSN:
0223-5234
URN:
uuid:335114b9-330a-4a3e-ac57-7bf7bb817191
Source identifiers:
382779
Local pid:
pubs:382779

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP