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Journal article

Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β cell are associated with glucose intolerance in humans and mice

Abstract:

Single nucleotide polymorphisms (SNPs) close to the VPS13C, C2CD4A and C2CD4B genes on chromosome 15q are associated with impaired fasting glucose and increased risk of type 2 diabetes. eQTL analysis revealed an association between possession of risk (C) alleles at a previously-implicated causal SNP, rs7163757, and lowered VPS13C and C2CD4A levels in islets from female (n=40; p<0.041) but not male subjects. Explored using promoter-reporter assays in β and other cell lines, the risk variant...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Author Accepted Manuscript

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Publisher copy:
10.1152/ajpendo.00074.2016

Authors


Pullen, TJ More by this author
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Publisher:
American Physiological Society Publisher's website
Journal:
American journal of physiology. Endocrinology and metabolism Journal website
Pages:
ajpendo.00074.2016
Publication date:
2016-06-21
DOI:
EISSN:
1522-1555
ISSN:
0193-1849
URN:
uuid:334b95d6-7137-41f0-83ac-2af9025381c2
Source identifiers:
631029
Local pid:
pubs:631029
Language:
English
Keywords:

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