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Engineering cytochrome-modified silica nanoparticles to induce programmed cell death

Abstract:

A low native membrane permeability and ineffective access to the cellular cytosol, together with aggressive proteolytic degradation, often severely hampers the practical application of any therapeutic protein or antibody. Through engineering the charging profile of mesoporous silica nanoparticles, cellular uptake and subsequent subcellular distribution can be controlled. We show herein that programmed cell death can subsequently be induced across a population of cancer cells with remarkable e...

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Publisher copy:
10.1002/chem.201303239

Authors


Journal:
Chemistry - A European Journal
Volume:
19
Issue:
52
Pages:
17891-17898
Publication date:
2013-12-23
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
URN:
uuid:33485b3f-85bd-4aea-beca-13fa164181c3
Source identifiers:
446033
Local pid:
pubs:446033

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