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Spatial memory dissociations in mice lacking GluR1.

Abstract:

Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3-CA1 long-term potentiation. We now report that they showed normal spatial reference learning and memory, both on the hidden platform watermaze task and on an appetitively motivated Y-maze task. In contrast, they showed a specific spatial working memory impairment during tests of non-matching to place on both the Y-maze and an elevated T-maze. In addition, successful watermaze and Y-maze refere...

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Publication status:
Published

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Publisher copy:
10.1038/nn910

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Schmitt, WB More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Journal:
Nature neuroscience
Volume:
5
Issue:
9
Pages:
868-873
Publication date:
2002-09-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:33259641-2f4d-4842-b2d4-5f84af459157
Source identifiers:
25355
Local pid:
pubs:25355

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