- Abstract:
-
Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3-CA1 long-term potentiation. We now report that they showed normal spatial reference learning and memory, both on the hidden platform watermaze task and on an appetitively motivated Y-maze task. In contrast, they showed a specific spatial working memory impairment during tests of non-matching to place on both the Y-maze and an elevated T-maze. In addition, successful watermaze and Y-maze refere...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/nn910
-
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- Journal:
- Nature neuroscience
- Volume:
- 5
- Issue:
- 9
- Pages:
- 868-873
- Publication date:
- 2002-09-05
- DOI:
- EISSN:
-
1546-1726
- ISSN:
-
1097-6256
- URN:
-
uuid:33259641-2f4d-4842-b2d4-5f84af459157
- Source identifiers:
-
25355
- Local pid:
- pubs:25355
- Copyright date:
- 2002
Journal article
Spatial memory dissociations in mice lacking GluR1.
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