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Model for a transcript map of human chromosome 21: isolation of new coding sequences from exon and enriched cDNA libraries.

Abstract:

The construction of a transcriptional map for human chromosome 21 requires the generation of a specific catalogue of genes, together with corresponding mapping information. Towards this goal, we conducted a pilot study on a pool of random chromosome 21 cosmids representing 2 Mb of non-contiguous DNA. Exon-amplification and cDNA selection methods were used in combination to extract the coding content from these cosmids, and to derive expressed sequences libraries. These libraries and the sourc...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/4.8.1291

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Journal:
Human molecular genetics
Volume:
4
Issue:
8
Pages:
1291-1304
Publication date:
1995-08-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Source identifiers:
73826
Language:
English
Keywords:
Pubs id:
pubs:73826
UUID:
uuid:3324fd44-0943-4513-82d5-85e66399a092
Local pid:
pubs:73826
Deposit date:
2012-12-19

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