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Selective permeabilization of the blood-brain barrier at sites of metastasis

Abstract:

BACKGROUND: Effective chemotherapeutics for primary systemic tumors have limited access to brain metastases because of the blood-brain barrier (BBB). The aim of this study was to develop a strategy for specifically permeabilizing the BBB at sites of cerebral metastases. METHODS: BALB/c mice were injected intracardially to induce brain metastases. After metastasis induction, either tumor necrosis factor (TNF) or lymphotoxin (LT) was administered intravenously, and 2 to 24 hours later gadoliniu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/jnci/djt276

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
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Funding agency for:
Connell, JJ
Publisher:
Oxford University Press Publisher's website
Journal:
J Natl Cancer Inst Journal website
Volume:
105
Issue:
21
Pages:
1634-1643
Publication date:
2013-11-05
DOI:
EISSN:
1460-2105
ISSN:
0027-8874
URN:
uuid:3321e614-e342-4fa1-9408-a41467b18b74
Source identifiers:
433443
Local pid:
pubs:433443

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