Journal article
Selective permeabilization of the blood-brain barrier at sites of metastasis
- Abstract:
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BACKGROUND: Effective chemotherapeutics for primary systemic tumors have limited access to brain metastases because of the blood-brain barrier (BBB). The aim of this study was to develop a strategy for specifically permeabilizing the BBB at sites of cerebral metastases. METHODS: BALB/c mice were injected intracardially to induce brain metastases. After metastasis induction, either tumor necrosis factor (TNF) or lymphotoxin (LT) was administered intravenously, and 2 to 24 hours later gadoliniu...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 855.3KB, Terms of use)
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- Publisher copy:
- 10.1093/jnci/djt276
Authors
Funding
Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- J Natl Cancer Inst More from this journal
- Volume:
- 105
- Issue:
- 21
- Pages:
- 1634-1643
- Publication date:
- 2013-11-05
- DOI:
- EISSN:
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1460-2105
- ISSN:
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0027-8874
Item Description
- Language:
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English
- Keywords:
-
- UUID:
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uuid:3321e614-e342-4fa1-9408-a41467b18b74
- Local pid:
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pubs:433443
- Source identifiers:
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433443
- Deposit date:
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2013-11-16
Terms of use
- Copyright holder:
- Connell et al
- Copyright date:
- 2013
- Notes:
- Copyright © 2013 Connell et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
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