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Journal article

Imperfect vaccination: some epidemiological and evolutionary consequences.

Abstract:

An aim of some vaccination programmes is to reduce the prevalence of an infectious disease and ultimately to eradicate it. We show that eradication success depends on the type of vaccine as well as on the vaccination coverage. Vaccines that reduce the parasite within-host growth rate select for higher parasite virulence and this evolution may both increase the prevalence of the disease and prevent disease eradication. By contrast, vaccines that reduce the probability of infection select again...

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Publication status:
Published

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Publisher copy:
10.1098/rspb.2003.2370

Authors


Mackinnon, M More by this author
Journal:
Proceedings. Biological sciences / The Royal Society
Volume:
270
Issue:
1520
Pages:
1129-1136
Publication date:
2003-06-05
DOI:
EISSN:
1471-2954
ISSN:
0962-8452
URN:
uuid:33141b03-0436-46cd-8916-f7154bb859e5
Source identifiers:
90476
Local pid:
pubs:90476

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