- Abstract:
-
An aim of some vaccination programmes is to reduce the prevalence of an infectious disease and ultimately to eradicate it. We show that eradication success depends on the type of vaccine as well as on the vaccination coverage. Vaccines that reduce the parasite within-host growth rate select for higher parasite virulence and this evolution may both increase the prevalence of the disease and prevent disease eradication. By contrast, vaccines that reduce the probability of infection select again...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1098/rspb.2003.2370
-
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- Journal:
- Proceedings. Biological sciences / The Royal Society
- Volume:
- 270
- Issue:
- 1520
- Pages:
- 1129-1136
- Publication date:
- 2003-06-05
- DOI:
- EISSN:
-
1471-2954
- ISSN:
-
0962-8452
- URN:
-
uuid:33141b03-0436-46cd-8916-f7154bb859e5
- Source identifiers:
-
90476
- Local pid:
- pubs:90476
- Copyright date:
- 2003
Journal article
Imperfect vaccination: some epidemiological and evolutionary consequences.
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