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Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.

Abstract:

Short-chain dehydrogenases/reductases (SDRs) constitute a large family of NAD(P)(H)-dependent oxidoreductases, sharing sequence motifs and displaying similar mechanisms. SDR enzymes have critical roles in lipid, amino acid, carbohydrate, cofactor, hormone and xenobiotic metabolism as well as in redox sensor mechanisms. Sequence identities are low, and the most conserved feature is an alpha/beta folding pattern with a central beta sheet flanked by 2 - 3 alpha-helices from each side, thus a cla...

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Journal:
Cellular and molecular life sciences : CMLS
Volume:
65
Issue:
24
Pages:
3895-906
Publication date:
2008-01-01
ISSN:
1420-9071
URN:
uuid:330452c0-d69d-4f2a-8c0a-40e38a10a1b7
Local pid:
SGC:19011750

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