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A transgenic mouse model of sickle cell disorder.

Abstract:

A single base-pair mutation (beta s) in codon 6 of the human beta-globin gene, causing a single amino-acid substitution, is the cause of sickle cell anaemia. The mutant haemoglobin molecule, HbS, polymerizes when deoxygenated and causes deformation of the erythrocytes to a characteristic 'sickled' shape. Sickling of cells in small vessels causes painful crises and other life-threatening complications. Although the molecular basis for sickle cell anaemia has been known for 30 years, no definit...

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Publication status:
Published

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Publisher copy:
10.1038/343183a0

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
Role:
Author
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Journal:
Nature
Volume:
343
Issue:
6254
Pages:
183-185
Publication date:
1990-01-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:3302dd47-aceb-464a-9729-24898e110ada
Source identifiers:
20665
Local pid:
pubs:20665

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