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Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection.

Abstract:

Recent studies suggest that natural killer T (NKT) cells play a role in early antiviral pathogenesis and are rapidly depleted in chronic human immunodeficiency virus type 1 (HIV-1) clade B infection. We aimed to characterize the phenotypic and functional characteristics of NKT cells in HIV-1 clade C-infected Africans at different stages of HIV-1 disease. NKT cell frequencies, subsets, and ex vivo effector functions were assessed using multiparametric flow cytometry in a cross-sectional analys...

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Publisher copy:
10.1089/aid.2010.0237

Authors


Mureithi, MW More by this author
Moodley, R More by this author
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Journal:
AIDS research and human retroviruses
Volume:
27
Issue:
5
Pages:
501-509
Publication date:
2011-05-05
DOI:
EISSN:
1931-8405
ISSN:
0889-2229
URN:
uuid:32ffe15a-feb2-480f-b144-667e31531244
Source identifiers:
191279
Local pid:
pubs:191279

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