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Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.

Abstract:
The synthesis and inhibitory potencies of a novel series of 3,5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3,5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried out previously and found to inhibit the growth of Mycobacterium tuberculosis.
Publication status:
Published

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Publisher copy:
10.1016/j.bmcl.2013.02.052

Authors


Abuhammed, A More by this author
Westwood, I More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Journal:
Bioorganic and medicinal chemistry letters
Volume:
23
Issue:
9
Pages:
2759-2764
Publication date:
2013-05-05
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
URN:
uuid:32ff5ecb-f8fb-464d-9367-fb39c71a2df1
Source identifiers:
399371
Local pid:
pubs:399371

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