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Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.

Abstract:

ATP-sensitive potassium channels (K-ATP channels) couple cell metabolism to electrical activity and are important in the physiology and pathophysiology of many tissues. In pancreatic beta-cells, K-ATP channels link changes in blood glucose concentration to insulin secretion. They are also the target for clinically important drugs such as sulphonylureas, which stimulate secretion, and the K+ channel opener diazoxide, which inhibits insulin release. Metabolic regulation of K-ATP channels is med...

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Publication status:
Published

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Publisher copy:
10.1038/387179a0

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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
Gribble, FM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Nature
Volume:
387
Issue:
6629
Pages:
179-183
Publication date:
1997-05-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:32fbc443-aea5-4051-a491-f76e94d589c7
Source identifiers:
3269
Local pid:
pubs:3269

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