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In vivo removal of malaria parasites from red blood cells without their destruction in acute falciparum malaria.

Abstract:

During acute falciparum malaria infection, red blood cells (RBC) containing abundant ring-infected erythrocyte surface antigen (Pf 155 or RESA), but no intracellular parasites, are present in the circulation. These RESA-positive parasite negative RBC are not seen in parasite cultures in vitro. This indicates that in acute falciparum malaria there is active removal of intraerythrocytic parasites by a host mechanism in vivo (probably the spleen) without destruction of the parasitized RBC. This ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Chotivanich, K More by this author
Udomsangpetch, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Journal:
Blood
Volume:
90
Issue:
5
Pages:
2037-2040
Publication date:
1997-09-05
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:32ea98da-5239-4e45-a768-8641b2634869
Source identifiers:
45660
Local pid:
pubs:45660

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