Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac disease.

Journal article

BACKGROUND: Coeliac disease (CD) is due to an inappropriate T cell mediated response to specific gluten peptides. Measured by interferon gamma (IFN-gamma) ELISPOT, about half of the gliadin specific T cells induced with in vivo wheat gluten exposure in HLA-DQ2+ CD are specific for an alpha/beta-gliadin peptide (p57-73 QE65; QLQPFPQPELPYPQPQS) that includes two overlapping T cell epitopes (PFPQPELPY and PQPELPYPQ). AIM: To define minimally substituted variants of p57-73 QE65 universally devoi...

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Authors: Anderson, R; van Heel, D; Tye-Din, J; Jewell, D; Hill, A

• Publication status: Published
• Journal: Gut
• Volume: 55
• Issue: 4
• Pages: 485-491
• Publication date: 2006-04-01
• DOI: 10.1136/gut.2005.064550
• EISSN: 1468-3288
• ISSN: 0017-5749
• Language: English
• Keywords: Humans; Interferon-gamma; Enzyme-Linked Immunosorbent Assay; Middle Aged; Adult; Cytokines; Leukocytes, Mononuclear; Amino Acids; Male; Triticum; Cells, Cultured; Aged; Peptide Fragments; Celiac Disease; T-Lymphocytes; Female; Epitopes, T-Lymphocyte; Gliadin