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Journal article

Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac disease.

Abstract:

BACKGROUND: Coeliac disease (CD) is due to an inappropriate T cell mediated response to specific gluten peptides. Measured by interferon gamma (IFN-gamma) ELISPOT, about half of the gliadin specific T cells induced with in vivo wheat gluten exposure in HLA-DQ2+ CD are specific for an alpha/beta-gliadin peptide (p57-73 QE65; QLQPFPQPELPYPQPQS) that includes two overlapping T cell epitopes (PFPQPELPY and PQPELPYPQ). AIM: To define minimally substituted variants of p57-73 QE65 universally devoi...

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Publication status:
Published

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Publisher copy:
10.1136/gut.2005.064550

Authors


Anderson, RP More by this author
van Heel, DA More by this author
Tye-Din, JA More by this author
Jewell, DP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Journal:
Gut
Volume:
55
Issue:
4
Pages:
485-491
Publication date:
2006-04-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:32def893-6ed7-432a-bfa4-51992890244d
Source identifiers:
53902
Local pid:
pubs:53902

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