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Journal article

Dense genomic sampling identifies highways of pneumococcal recombination.

Abstract:

Evasion of clinical interventions by Streptococcus pneumoniae occurs through selection of non-susceptible genomic variants. We report whole-genome sequencing of 3,085 pneumococcal carriage isolates from a 2.4-km(2) refugee camp. This sequencing provides unprecedented resolution of the process of recombination and its impact on population evolution. Genomic recombination hotspots show remarkable consistency between lineages, indicating common selective pressures acting at certain loci, particu...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2895

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Journal:
Nature genetics
Volume:
46
Issue:
3
Pages:
305-309
Publication date:
2014-03-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:32cb2abf-bf0c-4b75-9c61-4b2eb6d9df9c
Source identifiers:
449253
Local pid:
pubs:449253

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