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Selection for high and low virulence in the malaria parasite Plasmodium chabaudi.

Abstract:

What stops parasites becoming ever more virulent? Conventional wisdom and most parasite-centred models of the evolution of virulence suppose that risk of host (and, hence, parasite) death imposes selection against more virulent strains. Here we selected for high and low virulence within each of two clones of the rodent malaria parasite Plasmodium chabaudi on the basis of between-host differences in a surrogate measure of virulence--loss of live weight post-infection. Despite imposing strong s...

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Publication status:
Published

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Publisher copy:
10.1098/rspb.1999.0699

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Journal:
Proceedings. Biological sciences / The Royal Society
Volume:
266
Issue:
1420
Pages:
741-748
Publication date:
1999-04-05
DOI:
EISSN:
1471-2954
ISSN:
0962-8452
URN:
uuid:32c8c62c-3e3b-4405-8396-ddc2a8aa7d4c
Source identifiers:
90452
Local pid:
pubs:90452

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