Journal article
Mitochondrial DNA is a direct target of anti-cancer anthracycline drugs.
- Abstract:
-
The anthracyclines, such as doxorubicin (DXR), are potent anti-cancer drugs but they are limited by their clinical toxicity. The mechanisms involved remain poorly understood partly because of the difficulty in determining sub-cellular drug localisation. Using a novel method utilising the fluorescent DNA dye PicoGreen, we found that anthracyclines intercalated not only into nuclear DNA but also mitochondrial DNA (mtDNA). Intercalation of mtDNA by anthracyclines may thus contribute to the marke...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.bbrc.2008.11.059
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Bibliographic Details
- Journal:
- Biochemical and biophysical research communications
- Volume:
- 378
- Issue:
- 3
- Pages:
- 450-455
- Publication date:
- 2009-01-01
- DOI:
- EISSN:
-
1090-2104
- ISSN:
-
0006-291X
- Source identifiers:
-
248240
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:248240
- UUID:
-
uuid:32c48662-5d38-4ec7-8a66-dc34f2c6eaf9
- Local pid:
- pubs:248240
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2009
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