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Mitochondrial DNA is a direct target of anti-cancer anthracycline drugs.

Abstract:

The anthracyclines, such as doxorubicin (DXR), are potent anti-cancer drugs but they are limited by their clinical toxicity. The mechanisms involved remain poorly understood partly because of the difficulty in determining sub-cellular drug localisation. Using a novel method utilising the fluorescent DNA dye PicoGreen, we found that anthracyclines intercalated not only into nuclear DNA but also mitochondrial DNA (mtDNA). Intercalation of mtDNA by anthracyclines may thus contribute to the marke...

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Publication status:
Published

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Publisher copy:
10.1016/j.bbrc.2008.11.059

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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Role:
Author
Journal:
Biochemical and biophysical research communications
Volume:
378
Issue:
3
Pages:
450-455
Publication date:
2009-01-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:32c48662-5d38-4ec7-8a66-dc34f2c6eaf9
Source identifiers:
248240
Local pid:
pubs:248240

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