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The role of vascular myoglobin in nitrite-mediated blood vessel relaxation.

Abstract:

AIMS: This work investigates the role of myoglobin in mediating the vascular relaxation induced by nitrite. Nitrite, previously considered an inert by-product of nitric oxide metabolism, is now believed to play an important role in several areas of pharmacology and physiology. Myoglobin can act as a nitrite reductase in the heart, where it is plentiful, but it is present at a far lower level in vascular smooth muscle-indeed, its existence in the vessel wall is controversial. Haem proteins hav...

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Publication status:
Published

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Publisher copy:
10.1093/cvr/cvq299

Authors


Ormerod, JO More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Steeples, V More by this author
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Journal:
Cardiovascular research
Volume:
89
Issue:
3
Pages:
560-565
Publication date:
2011-02-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:32a49e93-aed1-4726-b0d6-f189d3fe25f1
Source identifiers:
120315
Local pid:
pubs:120315

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