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Journal article

Multiphoton high-resolution 3D imaging of Langerhans cells and keratinocytes in the mouse skin model adopted for epidermal powdered immunization.

Abstract:

Langerhans cells (LCs) can be targeted with DNA-coated gold micro-projectiles ("Gene Gun") to induce potent cellular and humoral immune responses. It is likely that the relative volumetric distribution of LCs and keratinocytes within the epidermis impacts on the efficacy of Gene Gun immunization protocols. This study quantified the three-dimensional (3D) distribution of LCs and keratinocytes in the mouse skin model with a near-infrared multiphoton laser-scanning microscope (NIR-MPLSM). Stratu...

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Publication status:
Published

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Publisher copy:
10.1038/sj.jid.5700290

Authors


Mulholland, WJ More by this author
Arbuthnott, EA More by this author
Bellhouse, BJ More by this author
Cornhill, JF More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
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Journal:
The Journal of investigative dermatology
Volume:
126
Issue:
7
Pages:
1541-1548
Publication date:
2006-07-05
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
URN:
uuid:32a0863d-6c9d-450a-8e88-5d390fb5b742
Source identifiers:
62033
Local pid:
pubs:62033

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