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Infection of lymphocytes by a virus that aborts cytotoxic T lymphocyte activity and establishes persistent infection.

Abstract:

For viruses to establish persistent infections in their hosts, they must possess some mechanism for evading clearance by the immune system. When inoculated into adult immunocompetent mice, wild-type lymphocytic choriomeningitis virus (LCMV ARM) induces a CD8(+)-mediated cytotoxic T lymphocyte (CTL) response that clears the infection within 7-14 d (CTL+ [P-]). By contrast, variant viruses isolated from lymphoid tissues of persistently infected mice fail to induce a CTL response and are thus ab...

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Publication status:
Published

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Publisher copy:
10.1084/jem.174.1.203

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Oldstone, MB More by this author
Journal:
The Journal of experimental medicine
Volume:
174
Issue:
1
Pages:
203-212
Publication date:
1991-07-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:3299aa62-89e9-4e51-8f7c-e8e399f28d23
Source identifiers:
34503
Local pid:
pubs:34503

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